Let’s be honest… Period pain has been ignored for far too long

If medals were handed out for surviving period symptoms, women would have their own Olympic ceremony every month.

We’ve dealt with cramps that could take out a grown adult, mood swings strong enough to shake the foundations of civilisation, and exhaustion that feels like a weighted blanket made of emotions.

And what do we get told?

“Just take something and lie down.”¹
“Have a rest.”
“It’s normal.”²

Except… you and I both know:
There is nothing “normal” about pain so intense it hijacks your life.

Up to 90% of Australian women experience significant menstrual pain or PMS³,  many losing work days, social days, and sanity days⁴.

So, when a world-first, peer-reviewed Australian clinical trial finally lands showing a natural, plant-derived product can significantly improve menstrual pain and PMS-related emotional symptoms?

We celebrate.
We scream.
We text every woman we know.

And here’s the kicker:

The clinical trial was conducted by Bioactive Natural Health,  the parent science company behind Hey Sister!

Meaning the same team that developed Khapregesic® is the same team empowering women through Hey Sister!.

And now?
One of Australia’s most respected OB-GYNs, Dr Talat Uppal, has publicly supported the published study,  calling it a major step forward in women’s health.

Let’s unpack it. Properly. Boldly. And with receipts.

Dr Talat Uppal: “This Is an Area That Is Historically Under-Researched.”

Before anything else:
Dr Talat did not run the study.
Bioactive Natural Health did.

But she is one of the loudest, most credible clinical voices supporting it.

In her interview, she said:

“This is an area that is historically under-researched.
It’s great to see a recent Australian study… which helps improve our menstrual understanding.
Clinical trials are important because this is typically an under-researched space.” ,  Dr Talat Uppal₉

And she’s right.
Menstrual pain and PMS have been medical blind spots for decades.

She went on to highlight why this trial matters:

“The study provided peer-reviewed insights.
It showed physical and psychological benefits and was well tolerated.”₉

And:

“The women had a reduction in daily menstrual pain rating, needed less additional analgesia, and reported improved psychological scores.”₉

Her final verdict?

“More research is needed into plant-based products in menstrual care,  but this is a very promising step.”₉

When a clinician like Dr Talat endorses research like this, it doesn’t just validate the science; it validates women.

The World-First Khapregesic® Clinical Trial: Conducted by Bioactive Natural Health

Now let’s talk about the science.

This wasn’t a casual “wellness trial”.
This was a randomised, double-blind, placebo-controlled study, published in the International Journal of Women’s Health.

Conducted by Bioactive Natural Health, the parent company behind Hey Sister!, the trial evaluated Khapregesic®, a plant-based menstrual support product.

Women aged 18–50 were tracked across two menstrual cycles.
The metrics included:

• menstrual pain

• PMS emotional symptoms

• physical discomfort

• Sleep

• daily functioning

• need for additional pain relief

• side effects
  

And the results?

Let’s say they turned heads.

Direct from the data₁₀:

136% More Pain Reduction Than Placebo

Significant Decrease in “Extra” Pain-Relief Use

Women needed way less backup support.

70% Improvement in Physical Symptoms

Including fatigue, insomnia and breast tenderness.

196% Improvement in Psychological Wellbeing

Mood swings
Anxiety
Irritability
Emotional volatility

All eased.

300% Improvement in Social Function

Women returned to exercise, work, social plans, and living their lives again.

Zero Treatment-Related Adverse Reactions

Even at triple dose.

This is what women have waited decades for:

A natural treatment proven to ease both physical and emotional PMS symptoms.

Why This Trial Matters (Especially If You've Ever Been Dismissed)

Women told us:

• Their pain was minimised

• Their emotional symptoms were mocked

• Their fatigue wasn’t believed

• Their PMS was shrugged off

• Their mental health dips were misunderstood
  

This trial finally aligns lived experience with measurable data,  as reinforced by the Australian Longitudinal Study on Women’s Health⁷.

Your cramps are real.
Your moods are real.
Your fatigue is real.
Your emotional chaos is real.

And now?

They’re clinically validated.

Where, Hey Sister! fits in: The daily support crew between scientific breakthroughs

Breakthrough clinical research is extraordinary.
But Hey Sister! is here for all the moments that research doesn’t see:

• The bloat

• The irritability

• The fatigue

• The tears in a toilet cubicle

• The PMS spirals

• The perimenopause plot twists

• the pre-period “everything feels wrong” days
  

Bioactive Natural Health brings the science.
Hey Sister! brings the daily support inspired by that science.

Our natural formulations are aligned with evidence from organisations like Jean Hailes⁸, supporting mood, calm, rest, and hormonal balance throughout your cycle.

Together?
It’s science and sisterhood,  the ultimate team-up.

Let’s Smash the Taboo, Finally

Women told us they are tired of:

• Being told their symptoms are “normal”

• Losing days every single month

• Feeling emotionally unpredictable

• Working through pain

• Suffering silently

• Being dismissed or ignored

This study marks a turning point.

And paired with Hey Sister!, women now have:

✔ Validation
✔ Natural daily support
✔ Psychological understanding
✔ Credible science
✔ A community
✔ Education
✔ Empowerment

This is what real women’s health looks like.
This is the future.

FAQ 

Who conducted the Khapregesic® clinical trial?

Bioactive Natural Health, the parent science company behind Hey Sister!.

Is this study peer-reviewed?

Yes, it was published in the International Journal of Women’s Health.

What does Dr Talat say about it?

She acknowledges the study is peer-reviewed, shows physical and psychological benefits, and highlights the need for more research in women’s health⁹.

Does Khapregesic® help with PMS?

The trial showed improvements in mood, irritability, anxiety and emotional wellbeing₁₀.

Is it safe?

The study reported zero treatment-related adverse events.