Khapregesic® is the main ingredient in all of our Hey Sister! Products.  Khapregesic® is a plant based, TGA listed medicine.  Developed with advanced technology, Khapregesic® retains the potent activity of the natural compounds found in the Khaya senegalensis tree (pronounced Ky-yar sen-ee-gal-en-sis), also known as Khaya (Ky-yar for short), allowing the mechanisms of action to work synergistically.

Khapregesic® is designed to deliver safe, fast-acting, and long-lasting relief from period pain, premenstrual syndrome (PMS), and menopausal symptoms, including psychological symptoms (such as mood swings and brain fog) and vasomotor effects (such as hot flashes and night sweats).

This single ingredient packs a powerful punch.  The first component of Khapregesic® is its anti-inflammatory effect, with Khapregesic® exhibiting selective COX-2 inhibition. This means it reduces pain and inflammation without the gastrointestinal side effects commonly seen in non-steroidal anti-inflammatory drugs, better known as NSAIDs. 

Secondly, Khapregesic® contains high levels of naturally occurring antioxidants. These are critical for cellular repair, maintaining the integrity of the gastrointestinal mucosal lining. 

Khapregesic® also provides microbiome modulation through unique, plant-derived prebiotic polysaccharides, a type of fibre that feeds the good bacteria living in your gut. 

OG Range (our original formula): is packed with our single hero ingredient Khapregesic® - specifically focusing on the therapeutic relief for those managing period pain & PMS.  OG is also HASTA certified, meaning this range is safe for athletes to use.  HASTA is the only laboratory in Australia able to provide independent Certification of sport supplements by testing for WADA prohibited substances.

Life Range: as with OG, Life is packed with our hero ingredient Khapregesic®, however each stage of our Life Range, from Teen Period through to Menopause, includes added vitamins that are critical to the wellbeing of a woman at each stage of Life.  The added vitamins have been carefully selected, by women, for women.  

Think of the Life range as a multivitamin designed for your specific stage of Life, with the added benefits of Khapregesic® - packing an even more powerful punch.

Yes! Hey Sister! (Khapregesic®) is an Australian Listed medicine with the TGA (Therapeutic Goods Administration). This means all Hey Sister! products meet Australia’s strict safety and quality standards. 

We are also backed by serious scientific evidence. A gold-standard, double-blind, placebo-controlled clinical trial (which is rare for natural products!) was completed early 2025 with outstanding results addressing both Period Pain and PMS symptoms.  If you're curious, you can check out the peer-reviewed study here: https://pubmed.ncbi.nlm.nih.gov/40672875/

You can also read more about all this on our science page - https://heysister.com/pages/our-science

Our Khaya Trees are grown in Western Australia on our own Hey Sister! Australian Certified Organic medicinal plantations, where it’s sustainably cultivated using patent-pending harvest technology, ensuring that our medicinal trees thrive post-harvest, creating a renewable natural resource while storing carbon to benefit the planet.

Every Hey Sister! The tablet is 100% Australian grown and made with no offshore processing, ever. It’s local, clean, and traceable from soil to shelf.

You can read more about this on our science page!
https://heysister.com/pages/our-science

As with any natural medicine, this can be different for everyone, our bodies are all unique and often get different results.  Even more importantly, everyone's pain journey is also completely different. Some say they notice a difference within 30 minutes, others say it takes up to 3 cycles.

Many people often make the mistake of not completing all 14 tablets during their cycle which means you may not notice the biggest impact. Below is a video of our Director of Health and Wellness, Jade Walker, speaking about why the 3 month rule to test a product in this case is important to allow you to feel a difference.

https://youtu.be/LXUr5JD8BQk?feature=shared

All Hey Sister! products have plant-based anti-inflammatories with high antioxidants and high prebiotics, found in our ingredient Khapregesic. This combination, even with food, can potentially lead to a shorter period by improving gut health and hormone balance. By reducing inflammation and supporting your gut's ability to metabolise estrogen, Hey Sister! can help regulate your cycle, which may lead to less prolonged bleeding. A healthy gut microbiome is linked to balanced hormone levels and reduced inflammation, which influence menstrual cycle length and flow.

Yes, Khapregesic® can be taken safely at any time and with any other food, supplement or medication.

Always follow the directions on the pack or the written directions from your practitioner and remember, if symptoms persist, talk to your health professional.

No, there are no known harmful side effects. In documented traditional medicine dating back to over 100 years of use, there are no known harmful side effects. In the recent double blind placebo clinical trial, 98% of participants reported good to excellent tolerability, and 91% experienced zero treatment-related adverse reactions, Khapregesic® represents a new gold standard for menstrual therapies, safely addressing both physical and emotional dimensions of hormonal distress. 

Hundreds of people now take Khapregesic® and there has not been one report of a harmful side effect.

Khapregesic® is not to be used if pregnant or likely to become pregnant. It is not recommended during breastfeeding. It is not recommended for children under the age of 12. 

Always follow the directions on the pack or the written directions from your practitioner and remember, if symptoms persist, talk to your health professional.

Take one or two tablet(s) (dosage depends on your choice of product) twice daily during your period or pain phase — or daily if your cycle symptoms are ongoing. Consistency over several cycles delivers the best results.

We recommend, if you can, start taking Hey Sister! 2-3 days before your period starts. This will help with any PMS symptoms such anxiety and mood swings. It also gets a head start on inflammation which is a major cause of pain during your period.

Then continue taking the tablets as recommended until your period is finished.

Yes, you can crush Hey Sister! tablets if swallowing them whole is difficult. They can be mixed with a little water, juice, or a spoonful of yoghurt. The tablets will still do their thing, just note the taste can be a bit earthy, so we suggest a little honey to help the mixture from being too bitter.

If your period is irregular, we recommend taking Hey Sister! at the first sign of PMS symptoms, or period pain.  Hey Sister! has been designed to be fast acting, this means that you can take is as soon as you start to feel the need.

You can purchase Hey Sister! directly on our website, it’s free shipping and we offer a money back guarantee if Hey Sister! Does not work for you.

Hey Sister! is also available in 700+ pharmacies. Find your nearest pharmacy using our store locator:
https://heysister.com/pages/find-a-store

We also offer a subscription model, which means each month, or quarter, we will automatically ship out your chosen Hey Sister! Product, ensuring you don’t ever run out, this is also a cheaper option for you.

Hey Sister! ships Australia-wide (and to selected international locations). Orders are usually processed within 1–2 business days, with tracking available once dispatched.

We ship our products worldwide from Australia using international express shipping. No matter where you are, we'll make sure your order reaches you as quickly as possible.

You can skip, reschedule, advance or cancel your subscription at any time using our subscription management portal.

Just login here using your email address (we will send you a one-time verification code).

Yes! All Hey Sister! products come with a no questions asked money back guarantee on any 1 transaction within the last year.

Read the full terms and conditions here.