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Noah B.

"Helps stabilise my mood nearly as much as *** and reduces my cramping so much that I don't need any other *** despite my ***."

Verified Buyer

Rachel A.

"I was skeptical but hopeful and surprisingly after just a day I felt this working! My pain is random and can happen anytime but lately almost daily, so this is a great solution for me."

Verified Buyer

Che D.

"At first, the price made me hesitant. But those awful period days cost me in lost work and ruined plans. Hey Sister! is an investment in me and my health and well-being"

Verified Buyer

Hey Sister! Period & PMS Relief*

Targeted Relief for Your Period and PMS.* Backed by science. Made for women.

Join the over 10,000 women who have transformed their cycles with Hey Sister! – a dual-action, plant-based solution clinically tested to support both pain and PMS.*

Powered by Khapregesic® and designed by women (yep, actually tested on us), it helps ease cramps, mood swings, and bloating* - so you can get back to being you.*

Available In-Store

We recommend new customers allow up to 3 menstrual cycles to see full benefits. Start with a discounted 3 month supply.

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If You Don't Fall Head Over Heels In Love With Our Products, We'll Give Your Money Back. Just Ask.

The Science Behind Hey Sister!

What Makes Hey Sister! Different?
A new kind of period support – made for real life, not just lab tests.

Hey Sister! uses the power of Khapregesic®, a clinically tested, plant-based ingredient that’s been tested on real women for over 12 years, including a double-blind, placebo-controlled gold standard clinical study.

Translation? This isn’t wellness fluff – it’s evidence-backed, body-loving support that delivers fast, targeted relief from both period pain and PMS symptoms.

What’s actually causing all this chaos?

Blame it on prostaglandins, those sneaky hormone-like chemicals that go into overdrive during your period. They fire up inflammation, which ramps up pain, cramps, bloating, fatigue and all the mood madness.

Hey Sister! helps ease symptoms by calming this inflammatory response, naturally, gently, and effectively. No synthetics. No band-aid fixes. Just smart support that works with your body.

So, Why Khapregesic®?

Straight from the Khaya Senegalensis tree, Khapregesic® combines:

Anti-inflammatory support to help ease pain and cramps*
High antioxidant levels to support fatigue, skin health, and mood*
Prebiotics to reduce bloating and support gut health*

Together, they offer a dual-action, plant-based solution for your full cycle, not just one symptom at a time.

Why Women Are Switching

Because we’re done being dismissed. Done with “it’s just your period.”Done with alternatives that barely take the edge off.

Hey Sister! is the evidence-based option we should’ve had years ago.

Natural, science-backed, and actually made for women. No side effects. No second-guessing. Just clearer cycles, calmer moods, and comfort you can feel good about.

What's Inside It?

Each tablet contains:

Khapregesic® 500 mg (Khaya Senegalensis Dry Stem Bark).

Our products are manufactured in Australia from Australian-grown certified-organic Khaya Senegalensis.

100% Plant-based active ingredient. No added artificial flavouring, colouring or preservatives.

Free from dairy, gluten, eggs, nuts, and yeast.

How Should I Take It?

Take 2 tablets daily, one in the morning and one in the evening, with or without food and continue for 7 days or as professionally prescribed.

If symptoms persist, talk to your health professional.

Children: Use in children under 12 years is not recommended.

Pregnancy: Do not take if you are likely to become pregnant, pregnant, or breastfeeding.

For a full set of directions always refer to the pack.

Click to Read More FAQs

Noah B.

"Helps stabilise my mood nearly as much as *** and reduces my cramping so much that I don't need any other *** despite my ***."

Verified Buyer

Rachel A.

"I was skeptical but hopeful and surprisingly after just a day I felt this working! My pain is random and can happen anytime but lately almost daily, so this is a great solution for me."

Verified Buyer

Che D.

"At first, the price made me hesitant. But those awful period days cost me in lost work and ruined plans. Hey Sister! is an investment in me and my health and well-being"

Verified Buyer

Just two tablets a day. That’s it.

Hey Sister! works with your body to support a calmer, more comfortable cycle, fast. It’s dual-action, plant-based formula designed to help ease both period pain and PMS symptoms*, including mood swings, fatigue, and bloating *– all with natural, targeted relief.

Backed by 12+ years of research and a gold-standard clinical trial, Hey Sister! offers support you can trust.

1. Strong Anti-Inflammatory Properties

Many period symptoms start with inflammation – especially cramps, pain, and general discomfort.Hey Sister! includes Khapregesic®, which supports your body’s natural inflammatory response, helping you feel better, faster – no “numbing” or harsh side effects.

2. Comes With High Antioxidant Levels

Oxidative stress can mess with your energy, mood, and mental clarity during your cycle.Hey Sister! is packed with plant-based antioxidants that support cell health, helping you stay energised and more emotionally balanced all month long.

3. Natural Prebiotics for Gut Support

Gut health plays a huge role in hormone balance and how you feel.That’s why Hey Sister! is infused with natural prebiotics to support digestion and reduce bloating – so you can feel light, clear, and more like you again..

Our Supporters

Honest Reviews From Real Women

Double-blind, placebo control, gold standard

Latest Clinical Trial Results:

136%

greater pain relief than placebo*

90%

Less reliance on pain meds*

196%

Improvement in psychological wellbeing* (think mood swings, anxiety, crying in the pantry)

300%

Better social functioning* (yep, that includes showing up to work and brunch)

70%

Improvement in physical wellbeing*

98%

Of the participants rated tolerability as good to excellent*

Expert Reviews

Trusted by Health Practitioners

Jade Walker

Director of Education, Hey Sister!
Naturopath (Bachelor of Health Science)

“I’ve been using Hey Sister! myself for nearly five years, and I’ve recommended it to countless women who’ve felt overlooked or dismissed when it comes to their cycle care.

After trying almost every natural remedy out there, this is the only product I’ve found that offers fast, effective support comparable to conventional options, without the harsh side effects.

But what makes it truly next-gen is how it goes beyond just pain relief. It supports tissue repair, gut health, emotional balance, and overall well-being. It’s comprehensive, clean, and finally puts women’s health first.

Honestly? It’s about bloody time.”

Caroline Robertson

Naturopath, Anatomy & Physiology Lecturer, and Women’s Health Specialist (35+ years experience).

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“Looking back at my own struggles with painful periods, I only wish something like Hey Sister! had existed sooner.

Now, with over three decades in women’s health, I’m genuinely proud to recommend it, especially to those who feel like they’ve tried everything and are still searching for real support.

You don’t have to just ‘put up with it’. By helping to address inflammation, a key driver behind cramps and PMS, Hey Sister! offers a gentle, herbal option that truly supports the body and brings relief.”

Frequently Asked Questions

Is Hey Sister! actually effective?

Yep, and we've got the science to prove it.

Powered by Khapregesic®, it’s been studied in a double-blind, placebo-controlled trial with standout results:

136% greater pain relief than placebo*
90% reduction in painkiller use
196% improvement in psychological wellbeing*
300% improvement in social functioning*

Plus, it’s been used in traditional Western herbal medicine for centuries to relieve menstrual discomfort, and now it's backed by gold-standard clinical evidence.*

What symptoms can it help with?

Hey Sister! Period offers comprehensive menstruation symptom relief and is proven to help reduce or relieve the following symptoms*:

Menstruation Pain / Dysmenorrhoea.
Menstrual Spasms / Cramps.
Heavy Menstruation / Periods.
Weariness / Tiredness / Fatigue / Feeling of Weakness.
Abdominal Bloating / Spasm.
Gastrointestinal Pain.
Occurrence of Premenstrual Tension Symptoms (PMS).
Feelings of Aggression / Irritability Associated with Premenstrual Tension.
Mood Changes / Mood Swings Associated with Premenstrual Tension.
Confusion Associated with Premenstrual Tension.
Symptoms of Mild Anxiety.
Symptoms of Heartburn.

How Long Until I See Results?

Most women feel the effects within 15 mins or an hour, even when taken mid-cycle.

For best results:

Start 1-2 days before your period (if you can)

Take 2 tablets daily (morning and evening) for 7 days

Continue for at least 3 cycles to experience full-cycle support. Everyone’s body is different, but this is fast-acting support you can feel.

How Should I Take It?

What's Inside Hey Sister! Period?

Each tablet contains:

Khapregesic® 500 mg (Khaya Senegalensis Dry Stem Bark).

Our products are manufactured in Australia from Australian-grown certified-organic Khaya Senegalensis.

100% Plant-based. No added artificial flavouring, colouring or preservatives.

Free from dairy, gluten, eggs, nuts, and yeast.

Can I Take It With Other Medications?

Hey Sister! can be taken with other medications, supplements, or foods. It’s formulated to be gentle and non-disruptive to your existing routine. If in doubt, have a chat with your health practitioner.

What If It Doesn't Work For Me?

Periods are complex, and our bodies even more so. But if you're one of the unlucky few who don't, don't stress, we got your back.

We provide all new customers with a "Love It Or Money Back" guarantee on all first orders - so there's nothing to lose and everything to gain from trying us out!

Don't be afraid to contact support if you find it doesn't work as expected or if you need help with proper use or dosing.

How Long Does Shipping Take?

Orders are dispatched within 24 hours (Mon-Fri)

Standard shipping takes 2–10 business days

Need it faster?

Select express shipping at checkout

You’ll get tracking info the moment it’s out the door.

How Do I Manage My Subscription?

You can manage your subscriptions and view order history by logging in and navigating to heysister.com/account.

Alternatively, contact our support at hello@heysister.com, or leave us a message on our live chat.

Customer Reviews

What Our Customers Say About Hey Sister!

What's Inside?

Meet Khapregesic® – Backed by 12 Years of Science. Loved by 10,000+ Women.

Say goodbye to your period nightmares with Hey Sister! - the natural, effective, and safe remedy you’ve been waiting for to better manage your period symptoms.

Our solo, hero ingredient is Khapregesic®, an exclusive formulation from the Khaya Senegalensis tree, a remarkable ingredient known for its potent anti-inflammatory properties.

This plant-based hero doesn’t just mask your period symptoms like other period remedies do - it actually gets to the root cause of them, by targeting the inflammation creating those nasty symptoms you experience before, during and after your period week.

How does Hey Sister! work? It’s simple: most period symptoms stem from an overproduction of prostaglandins during menstruation, which causes excess inflammation in your body. By reducing this inflammation, Hey Sister! tackles the root cause, offering real symptom relief* that lasts.

"Khaya [our hero active ingredient] appears to have a very low toxicity risk... Potency is high and efficacy is reached at very low doses" ^[5]

introducing-jade-walker-our-director-of-health-and-wellness-931954.webp__PID:66a48f48-bc0a-4856-84a7-39743119817c

What a Skeptic Turned Fan Had to Say About Hey Sister!

Our products aren't going viral because of fancy packaging... It's because they work incredibly well for the women using them every month for their period. But we can appreciate the skepticism around new products - like ours - which come with big bold promises. So rather than just giving you our word, listen to what Tia - a skeptical customer - had to say about us:

"I thought it actually was a gimmick... How can a natural plant-based tablet help your cramps... There's something in this that has helped with the cramping... I'm able to go about my day now... It's legit..."

tia TT.webp__PID:0bb93e24-61ee-445f-b4db-4c22bb4bd109

Tia Jaie.

@tia.jaiee. 19.12K Followers

Disclaimer: This is a honest and genuine review of Hey Sister! Period from Tia (@tia.jaiee on TikTok). We did not pay or compensate her in any way, shape or form for this review and the statements she made about our products in this testimonial video.

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*Regulatory claims

*A Khaya senegalensis preparation known as Khapregesic®. Scientific evidence: Lopresti A. et al. "An examination into the safety and efficacy of Khapregesic®, a Khaya senegalensis preparation, on pain, physical and emotional wellbeing in women experiencing menstrual distress: a randomised, double-blind, placebo-controlled trial". Funded by Bioactive Natural Health Pty Ltd. To view and download the entire clinical trial published manuscript, click here. Traditional paradigm: Traditionally used in western herbal medicine to: [PERIOD] relieve menstruation pain, reduce occurrence of abdominal bloating, relieve symptoms of mild anxiety, reduce mood swings associated with premenstrual tension, [MENOPAUSE] reduce occurrence of menopausal symptoms, relieve symptoms of mild anxiety, reduce heavy menstruation (during peri-menopause). Always read the back of the pack and if symptoms persist, seek the advice of a healthcare professional.

© Hey Sister! 2024 BioActive Natural Health Pty Ltd

Sources

[5] Barg, C., & Robertson, C. (2019). Khaya senegalensis: Discover Khaya, the period pain reliever. Journal of the Australian Traditional Medicine Society, 25(3), 148. ISSN 1326-3390.

[4] Direct, H. (2024) Liver failure, healthdirect.gov.au. Available at: https://www.healthdirect.gov.au/liver-failure#:~:text=low%20blood%20pressure-,Paracetamol%20overdose%20is%20the%20most%20common%20cause%20of%20acute%20liver,Centre%20on%2013%2011%2026. (Accessed: 2024).

[3] Gow PJ, Jones RM, Dobson JL, Angus PW. Etiology and outcome of fulminant hepatic failure managed at an Australian liver transplant unit. J Gastroenterol Hepatol 2004; 19: 154-159.

[2] CHARACTERIZATION OF BIOACTIVE PHYTOCHEMICALS FROM THE STEM BARK OF AFRICAN MAHOGANY Khaya senegalensis (MELIACEAE) Huaping Zhang 12-2008; https://tigerprints.clemson.edu/all_dissertations/305/. Journal of the Australian Traditional Medicine Society Vol25 No3 2019 pp146-149. Journal of the Australian Natural Therapists Association Vol34 No3 2020 pp63-65

[1] Anticancer Research (2006) 26(3 B) 2397-2405 Chemopreventive effects of Khaya senegalensis bark extract on human colorectal cancer; Androulakis X, Muga S, Chen F, et al; https://www.mendeley.com/catalogue/f7090483-0e6d-300e-8a4e-8ba7ac808564/. Journal of the Australian Traditional Medicine Society Vol25 No3 2019 pp146-149. Journal of the Australian Natural Therapists Association Vol34 No3 2020 pp63-65

Peace of Mind shopping

Try Hey Sister! Love it or It’s Free.

We believe in Hey Sister! so much that if your not satisfied, we’ll refund your purchase. Up to one transaction, within a year of purchase date. No questions asked. You’ve got nothing to lose.
T&Cs apply.

*Regulatory claims

*A Khaya senegalensis preparation known as Khapregesic®. Scientific evidence: [PERIOD] Lopresti A. et al. "An examination into the safety and efficacy of Khapregesic®, a Khaya senegalensis preparation, on pain, physical and emotional wellbeing in women experiencing menstrual distress: a randomised, double-blind, placebo-controlled trial". [MENOPAUSE] Lopresti A. et al. " An examination into the safety and efficacy of Khapregesic®, a Khaya senegalensis preparation, on physical, and psychological wellbeing in women experiencing menopausal symptoms: a randomised, double-blind, placebo-controlled trial.” Both trials funded by Bioactive Natural Health Pty Ltd. View and download the [Period] clinical trial on PubMed. The Menopause clinical trial is due to be published in late 2026. Traditional paradigm: Traditionally used in western herbal medicine to: [PERIOD] relieve menstruation pain, reduce occurrence of abdominal bloating, relieve symptoms of mild anxiety, reduce mood swings associated with premenstrual tension, [MENOPAUSE] reduce occurrence of menopausal symptoms, relieve symptoms of mild anxiety, reduce heavy menstruation (during peri-menopause). Always read the back of the pack and if symptoms persist, seek the advice of a healthcare professional.