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⭐️ ⭐️ ⭐️ ⭐️ ⭐️ 4.7 Star Rating And 6000+ Happy Customers

Is The Hype For This New “Upgraded Painkiller” Justified?

Clinically-formulated for direct symptom support, without the nasties.

A world-first, all-natural formula developed to help relieve mild period pain and PMS symptoms.

Relief Against Intense Period Cramps and Pains
Reduces Mood Swings and PMS
Provides Support Against Fatigue
Reduces Bloating and Promotes Gut Health

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Why Conventional Pain Relief Doesn’t Always Cut It

You know the drill: take the tablet, hope for the best, and wait it out. But when your period brings full-body cramps, relentless bloating, or mood swings that hijack your week? That little white pill barely scratches the surface.

And here’s the reality most don’t talk about:

Most conventional options only target pain, not the full spectrum of symptoms like bloating, fatigue or mood swings
They don’t support gut health (and may actually impact it over time)
Long-term or frequent use has been linked to gut irritation, and liver and kidney strain
Paracetamol overdose is the most common cause of acute liver failure in Australia [3][4]

So What Makes Hey Sister! Different?

"Khaya [our hero active ingredient] appears to have a very low toxicity risk... Potency is high and efficacy is reached at very low doses" ^[5]

Hey Sister! Wasn’t built to mask symptoms; it was made to help your body feel genuinely better.

This clinically-proven, plant-based formulation supports women dealing with more than “just cramps”, think bloating that won’t quit, mood swings that mess with your day, and fatigue that hits like a truck.

Here’s how it’s different:

Multi-symptom support, PMS, bloating, fatigue, mood and more
Clinically-proven relief with no reported side effects in trials
Well tolerated, even at triple the dose
Supports gut and gastrointestinal wellbeing

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How Does It Work? Just Take 2 A Day.

One in the morning. One at night. That’s it.

Hey Sister! is clinically formulated to support your body through your cycle, not just during it. With consistent use, it targets the root causes of intense period symptoms like cramps, mood swings, bloating and fatigue.

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1. Potent Anti-Inflammatory Support

Inflammation is a major driver of discomfort. Our hero ingredient helps calm that internal fire, so you’re not just coping, you’re actually finding relief.

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2. Antioxidant-Rich for Energy + Mood

Oxidative stress can drag your mood down and leave you drained. Antioxidants in Hey Sister! help rebalance and revitalise, supporting energy, calm and clarity.

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3. Prebiotics for Gut + Bloat Relief

Formulated with natural prebiotics to support your gut and microbiome, which means less bloating, better digestion, and more feeling-like-yourself-again vibes.

Clinically Tested. Independently Conducted.

*Results from double-blind, placebo-controlled study of Khapregesic® [6]

136%

greater reduction in period pain than placebo⁺

90%

Reduction in the use of other pain-relieving medications⁺

70%

Greater improvement in physical wellbeing (including fatigue and sleep issues)⁺

196%

greater improvement in emotional wellbeing (covering anxiety, mood swings, etc.)⁺

300%

Greater improvement in social functioning (fewer days off, more daily activity)⁺

91%

Of participants reported no treatment-related side effects, even when taking up to 3x the standard daily dose.⁺

Expert-Approved

Trusted by Health Practitioners

Jade Walker

Director of Education, Hey Sister! and Naturopath (Bachelor of Health Science)

I’ve been using Hey Sister! for almost five years now. I used to experience intense period pain and had tried just about every natural remedy under the sun. It has become a key tool in how I support clients who are looking for a plant-based, well-tolerated alternative to manage symptoms such as cramps, fatigue, and bloating.

And it’s not just about pain relief. This is a next-generation solution that’s rich in plant polyphenols, supporting tissue repair, gut health, and overall wellbeing. It’s about bloody time we had a better option — and Hey Sister! is it.

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Caroline Robertson

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Reflecting on my own history with painful periods, I wish I’d had Hey Sister! Period sooner. But I’m profoundly grateful to share it now - especially with women who feel like they’ve tried everything else to no avail. You don’t have to silently endure crippling cramps. Confront the real root of your period torment - inflammation - with a safe, herbal solution that genuinely works.

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Noah B.

"Helps stabilise my mood nearly as much as *** and reduces my cramping so much that I don't need any other painkillers despite my ***."

Verified Buyer

Rachel A.

"I was skeptical but hopeful and surprisingly after just a day I felt this working! My pain is random and can happen anytime but lately almost daily, so this is a great solution for me."

Verified Buyer

Hey Sister! Period.

Backed by science and proven to help relieve intense period symptoms and promote overall wellness for women.

We recommend new customers allow up to 3 menstrual cycles to see full benefits. Start with a discounted 3 month supply.

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No time limits. No hoops. If you’re not head-over-heels, just ask, we’ll refund you.

The Science Behind Hey Sister!

Hey Sister! Period isn’t just plant-based, it’s clinically-formulated and practitioner-supported. Our hero ingredient, Khapregesic®, is backed by clinical trials and traditionally used in Western herbal medicine to relieve multiple menstrual symptoms, including pain, bloating, fatigue and mood swings.

What Triggers Period Symptoms?
Symptoms like cramps, bloating, and fatigue are often driven by an overproduction of prostaglandins, a hormone-like compound that increases inflammation and intensifies pain and uterine contractions. When prostaglandin levels spike, symptoms do too.

How Does Khapregesic® Help?
Khapregesic® contains a single, natural ingredient traditionally used to support:
- Healthy inflammatory response
- Gut health (thanks to naturally occurring prebiotics)
- Antioxidant protection against oxidative stress

In a clinical trial, Khapregesic® showed significant improvements across common menstrual symptoms—with no adverse events reported.

Why Thousands of Women Are Switching
There’s no one-size-fits-all when it comes to period care. But when you want something gentle and genuinely effective?

Hey Sister! is here with a natural, hormone-free alternative to standard options. Each tablet supports you from the inside out—with ingredients that not only target discomfort, but also nurture gut health, balance mood and energy, and help you feel more like yourself again.

No nasties. No synthetics. Just plant-powered support, month after month.

What's Inside It?

Each tablet contains:

Khapregesic® 500 mg (Khaya Senegalensis Dry Stem Bark).

Our products are manufactured in Australia from Australian-grown certified-organic Khaya Senegalensis.

100% Plant-based. No added artificial flavouring, colouring or preservatives.

Free from dairy, gluten, eggs, nuts, and yeast.

Hey Sister! is regulatory approved. Registration numbers AUST L 315762, 407536, 407537.

How Should I Take It?

Take 2 tablets daily, one in the morning and one in the evening, with or without food and continue for 7 days or as professionally prescribed.

If symptoms persist, talk to your health professional.

Children: Use in children under 12 years is not recommended.

Pregnancy: Do not take if you are likely to become pregnant, pregnant, or breastfeeding.

For a full set of directions always refer to the pack.

Click to Read More FAQs

Noah B.

"Helps stabilise my mood nearly as much as anti-anxiety meds and reduces my cramping so much that I don't need any other painkillers despite my endo"

Verified Buyer

Rachel A.

"I was skeptical but hopeful and surprisingly after just a day I felt this working! My pain is random and can happen anytime but lately almost daily, so this is a great solution for me."

Verified Buyer

Thousands of Women Say It Best...

We’re not going viral for our packaging. We’re going viral because this actually works. But hey, we get it. When something sounds too good to be true, scepticism is natural. That’s exactly how Tia felt before trying Hey Sister! for the first time.

"I thought it actually was a gimmick... How can a natural plant-based tablet help your cramps... There's something in this that has helped with the cramping... I'm able to go about my day now... It's legit..."

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Tia Jaie.

@tia.jaiee. 19.12K Followers

Disclaimer: This is a honest and genuine review of Hey Sister! Period from Tia (@tia.jaiee on TikTok). We did not pay or compensate her in any way, shape or form for this review and the statements she made about our products in this testimonial video.

Customer Reviews

What Our Customers Say About Hey Sister!

Frequently Asked Questions

Is It Actually Effective?

Yes, Hey Sister! is a genuinely effective solution to reduce your period pains, cramps and other mensuration symptoms. Besides the fact it’s been used for centuries in Western herbal medicine to reduce inflammation and pain, research and clinical studies can back up the claims we make about the effects of our products.

We're one of the few companies in the women's health space that takes efficacy seriously and have spent our own money to put our products to the test in clinical settings. We have a few recent observational trials underway and are committed to releasing the findings once they've concluded - as we've done with previous trials.

What Symptoms Can It Relieve?

Hey Sister! Period offers comprehensive menstruation symptom relief and is proven to help reduce or relieve the following symptoms:

Menstruation Pain / Dysmenorrhoea.
Menstrual Spasms / Cramps.
Heavy Menstruation / Periods.
Weariness / Tiredness / Fatigue / Feeling of Weakness.
Abdominal Bloating / Spasm.
Gastrointestinal Pain.
Occurrence of Premenstrual Tension Symptoms (PMS).
Feelings of Aggression / Irritability Associated with Premenstrual Tension.
Mood Changes / Mood Swings Associated with Premenstrual Tension.
Breast Pain / Tenderness Associated with Premenstrual Tension.
Confusion Associated with Premenstrual Tension.
Symptoms of Mild Anxiety.
Symptoms of Heartburn.

Is It Safe? Are There Any Side Effects?

Yes, Hey Sister! is considered safe for use every period cycle. Out of all the research done on our active ingredients, there's not been one report of harmful side effects. Additionally, a part of what makes Hey Sister so safe to use especially, on a regular basis is the fact that our active ingredients are water soluble and will flush out the body just like a vitamin would once you stop taking it - there's no build-up, lingering effects, or tolerance build-up.

How Long Until I See Results?

With Hey Sister! Period, most customers report immediate results - at worst - you'll feel the difference same day you start taking it regardless of when you start taking it during your period.

For best results, we recommend you start dosage 1-2 days before your period, or at least as soon as you experience symptoms.

For full, comprehensive results, we recommend taking Hey Sister! for at least 3-period cycles.

If you're skeptical about our products working for you, we provide all new customers with a "Love It Or Money Back" guarantee on all first orders - so there's nothing to lose and everything to gain from trying us out!

How Should I Take It?

Take 2 tablets daily, one in the morning and one in the evening, with or without food and continue for 7 days or as professionally prescribed.

If symptoms persist, talk to your health professional.

Children: Use in children under 12 years is not recommended.

Pregnancy: Do not take if you are likely to become pregnant, pregnant, or breastfeeding.

For a full set of directions always refer to the pack.

What's Inside Hey Sister! Period?

Each tablet contains:

Khapregesic® 500 mg (Khaya Senegalensis Dry Stem Bark).

Our products are manufactured in Australia from Australian-grown certified-organic Khaya Senegalensis.

100% Plant-based. No added artificial flavouring, colouring or preservatives.

Free from dairy, gluten, eggs, nuts, and yeast.

Hey Sister! is regulatory approved. Registration numbers AUST L 315762, 407536, 407537.

Can I Take It With Other Medications?

Yes, Hey Sister! can be taken safely at any time and with any other food, supplement or medication.

What If It Doesn't Work For Me?

Periods are complex, and our bodies even more so. We would be  surprised if you didn't feel any benefit from taking Hey Sister! especially when taken as directed. But if you're one of the unlucky few who don't, don't stress, we got your back.

We provide all new customers with a "Love It Or Money Back" guarantee on all first orders - so there's nothing to lose and everything to gain from trying us out!

Don't be afraid to contact support if you find it doesn't work as expected or if you need help with proper use or dosing.

How Long Does Shipping Take?

Orders are processed and dispatched within 24 hours of being received (during weekdays) and should arrive approximately 2 – 10 working days from dispatch depending on the address location.

Although once we ship it out, delivery times are out of our control and subject to Australia Post shipping times, we'll do our best to ensure a speedy arrival and assist with any shipping related support questions or concerns you have.

If you need a speedy delivery we offer a discounted express shipping option, just select it at checkout.

How Do I Manage My Subscription?

You can manage your subscriptions and view order history by logging in and navigating to heysister.com/account.

Alternatively, contact our support at support@heysister.com, or leave us a message on our live chat.

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*Regulatory claims

Traditionally used in western herbal medicine to: [PERIOD] relieve menstruation pain, reduce occurrence of abdominal bloating, relieve symptoms of mild anxiety, reduce mood swings associated with premenstrual tension, [MENOPAUSE] reduce occurrence of menopausal symptoms, relieve symptoms of mild anxiety, reduce heavy menstruation (during peri-menopause).

Always read the back of the pack and if symptoms persist, seek the advice of a healthcare professional.

Regulatory Reg. Nos. AUST L 315762, 407536, 407537. AU and US Certified-Organic No: 11640

© Hey Sister! 2024 BioActive Natural Health Pty Ltd

Sources

[6] Lopresti A. et al. "An examination into the safety and efficacy of Khapregesic®, a Khaya senegalensis preparation, on pain, physical and emotional wellbeing in women experiencing menstrual distress: a randomised, double-blind, placebo-controlled trial". Funded by Bioactive Natural Health Pty Ltd.

[5] Barg, C., & Robertson, C. (2019). Khaya senegalensis: Discover Khaya, the period pain reliever. Journal of the Australian Traditional Medicine Society, 25(3), 148. ISSN 1326-3390.

[4] Direct, H. (2024) Liver failure, healthdirect.gov.au. Available at: https://www.healthdirect.gov.au/liver-failure#:~:text=low%20blood%20pressure-,Paracetamol%20overdose%20is%20the%20most%20common%20cause%20of%20acute%20liver,Centre%20on%2013%2011%2026. (Accessed: 2024).

[3] Gow PJ, Jones RM, Dobson JL, Angus PW. Etiology and outcome of fulminant hepatic failure managed at an Australian liver transplant unit. J Gastroenterol Hepatol 2004; 19: 154-159.

[2] CHARACTERIZATION OF BIOACTIVE PHYTOCHEMICALS FROM THE STEM BARK OF AFRICAN MAHOGANY Khaya senegalensis (MELIACEAE) Huaping Zhang 12-2008; https://tigerprints.clemson.edu/all_dissertations/305/. Journal of the Australian Traditional Medicine Society Vol25 No3 2019 pp146-149. Journal of the Australian Natural Therapists Association Vol34 No3 2020 pp63-65

[1] Anticancer Research (2006) 26(3 B) 2397-2405 Chemopreventive effects of Khaya senegalensis bark extract on human colorectal cancer; Androulakis X, Muga S, Chen F, et al; https://www.mendeley.com/catalogue/f7090483-0e6d-300e-8a4e-8ba7ac808564/. Journal of the Australian Traditional Medicine Society Vol25 No3 2019 pp146-149. Journal of the Australian Natural Therapists Association Vol34 No3 2020 pp63-65